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What Is Modafinil?
Modafinil is a medication that is used to promote wakefulness and improve alertness in people who experience excessive sleepiness due to certain conditions; like narcolepsy, sleep apnea, or shift work sleep disorder. It is also sometimes used off-label to enhance cognitive function, memory, and focus.
How Does Modafinil Work?
The exact mechanism by which modafinil works are not fully understood. But it is however believed that modafinil affects several neurotransmitters in the brain; including dopamine, norepinephrine, histamine, and orexin/hypocretin.
Norepinephrine and Dopamine are neurotransmitters whose levels can be both increased by modafinil and they both play a role in promoting alertness and wakefulness. Modafinil increases the levels of these neurotransmitters in certain areas of the brain; such as the hypothalamus and amygdala, which may help to promote wakefulness.
Histamine is another neurotransmitter involved in regulating wakefulness and alertness. Modafinil is believed to increase the release of histamine in the brain, which may contribute to its wakefulness-promoting effects.
Finally
modafinil also affects the levels of orexin/hypocretin; which are neurotransmitters that are involved in regulating sleep-wake cycles. Orexin/hypocretin is produced in the hypothalamus and helps to promote wakefulness during the day. Modafinil has been shown to increase the release of orexin/hypocretin in the brain, which may also contribute to its wakefulness-promoting effects.
What Are The Side Effects Of Modafinil
Like all medications, modafinil can cause side effects, although not everyone who takes it will experience them. Common side effects of modafinil include:
Headache
Nausea
Dizziness
Dry mouth
Insomnia
Anxiety
Nervousness
Diarrhea
Indigestion
Back pain
Stuffy nose
In rare cases, modafinil can cause more serious side effects, including:
Severe skin reactions
Hypersensitivity reaction
Psychiatric symptoms
Cardiovascular events
Seizures
How To Take Modafinil
For Effective Treatment Of ADHD, Narcolepsy, And Sleep Disorder
The recommended dose of modafinil can vary depending on the specific condition being treated; as well as individual factors such as age, weight, and medical history. Therefore, it is important to follow your healthcare provider’s instructions when taking modafinil and not exceed the recommended dosage.
For the treatment of sleep apnea or narcolepsy, the usual recommended dose of modafinil is 200 mg per day; taken orally in the morning.
For the treatment of ADHD, the usual recommended dose of modafinil is also 200mg per day, taken orally in the morning. However, some healthcare providers may start with a lower dose of modafinil and gradually increase it based on your response to the medication.
Modafinil should be taken with a full glass of water, with or without food. Avoid taking modafinil too late in the day, as it may interfere with sleep.
